Proteomics Tools

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Cytokine Antibody Arrays—Human, Mouse, Rat


Product Summary

	Cytokine Arrays detect detect proteins involved in inflammation, atherosclerosis, growth factors, adipokines, angiogenesis, chemokines, and MMPs

Product Features

	•	Simultaneous detection of up to 174 cytokines in a single experiment - Saves time, cost, and sample, as compared to ELISA

	•	Highly specific, sensitive, and reliable - Most proteins detected at pg levels

	•	Cost effective, accurate, and reproducible

	•	Requires as little as 100 μL of sample for membrane arrays and 10 μL for glass slide arrays

	•	Compatible with many sample types - Including serum, cell culture supernates, cell and tissue lysates, and a wide range of body fluids

	•	Both glass slide and membrane formats available

	•	Full range of technical support and related services


Typical Applications

	•	Profiling cytokine expressions, monitoring cytokine/chemokine levels

	•	Identifying potential molecular targets for drug development

	•	Identifying crucial factors in disease processes

	•	Screening biomarkers for disease management

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Quantibody®—Quantitative Antibody Arrays


Product Summary

	Quantibody arrays are a multiplex, sandwich ELISA system combining the advantages of ELISA high-detection sensitivity and the high throughput capability of an array format

Product Features

	•	Multiple cytokine-specific capture antibodies are arrayed on a glass slide - Measure up to 40 cytokine levels in one experiment - Quantification of your sample is achieved by simultaneous assay with cytokines of predetermined concentration

	•	Similar or better sensitivity than ELISA

	•	Cost effective, accurate, and reproducible

	•	Requires as little as 50 μL of sample

	•	Compatible with many sample types - Including serum, plasma, conditioned media, cell lysates, and a wide range of body fluids

	•	Fluorescent detection method produces a wide dynamic range - Two orders higher than chemiluminescence - Enables discrete levels of specific cytokines to be measured

	•	Full range of technical support and testing services


Typical Applications

	•	Identifying and validating potential molecular targets for drug development

	•	Identifying and validating crucial factors in disease processes

	•	Screening biomarkers for disease management

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Phosphorylation Antibody Arrays—Human RTK and EGFR


Product Summary

	Phosphorylation antibody arrays are glass chips or membranes printed with RTK-specific or phospho-specific EGFR antibodies. They eliminate the need and expense of Western Blots and/or immunnoprecipitation analysis

Product Features

	•	Simultaneously detects relative phosphorylation levels of multiple proteins

	•	Easy to use—no special equipment required

	•	Minimizes hands-on time—convenient, semi-quantitative, and non-radioactive material

	•	Works reliably with wide range of cell lines, high sensitivity

	•	Full range of technical support and related services


RTK Phosphorylation Antibody Array

	•	A single array detects relative levels of phosphorylation for 71 human RTKs

	•	Chemiluminescent or flourescent detection

	•	Monitor cell signal transduction pathway, relative level of tyrosine RTK phosphorylation, and protein kinase activity


EGFR Phosphorylation Antibody Array

	•	A single array detects relative levels of phosphorylation at 17 specific sites of the EGFR family

	•	Screens for the effects of treatments, activators, or inhibitors on cell signaling, development, and growth

	•	Chemiluminescent detection

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Label-Based Antibody Arrays—Human, Mouse, Rat


Product Summary

	Label-based antibody arrays simultaneously detect the expression levels of 507 human proteins, 182 human adipokines, 308 mouse proteins, or 90 rat proteins

Product Features

	•	A single array detects the expression and modification levels of several hundred target proteins in your sample - Including cytokines, chemokines, adipokines, matrix metalloproteinases, growth factors, angiogenic factors, soluble receptors, and cell adhesion molecules

	•	Direct biotin labeling of proteins

	•	Highly specific, sensitive, and reproducible

	•	Internal control monitors the entire process—delivers accurate reflection of available cytokines

	•	A higher throughput, more accurate alternative to Western blotting and immunoprecipitation

	•	Easy to use—no special equipment required

	•	Both glass chip and membrane formats available

	•	Full range of technical support and related services


Typical Applications

	•	Identification of key factors and protein modifications

	•	Identification of drug targets and screening of biomarkers

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Protein Arrays—Human, Mouse


Product Summary

	Human and mouse protein arrays are recombinant or purified proteins, spotted in triplicate onto the surface of a glass chip

Product Features

	•	Broad applications for biomarker and drug discovery, early detection of disease, and biomedical research

	•	Detect expression of hundreds of proteins or protein modifications in a single sample

	•	Compatible with nearly any sample type and with most gene microarray scanners

	•	Highly specific, sensitive, and reliable

	•	Easy to use

	•	Full range of technical support and testing services


Typical Applications


	•	Detection of protein–protein interaction

	•	Monitoring of auto-antibody expression

	•	Characterization of antibody specificity

	•	Identification of protein modification

	•	Examination of protein and small molecule interaction

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ELISA Kits—Human, Mouse, Rat


Product Summary

	ELISA Kits employ a specific capture antibody coated on a 96-well plate, with the target protein sandwiched between the capture antibody and a biotinylated antibody. These assays require as little as 100 μL of sample to detect up to 120 cytokines

Product Features

	•	Available for human, mouse, or rat species

	•	Complete kit with pre-coated 96-well strip plate - Includes all necessary components to complete the test

	•	Highly sensitive and specific - Most proteins can be detected at pg levels

	•	Cost effective, accurate, and reproducible

	•	Many kits compatible with cell and tissue lysates

	•	Full range of technical support and related services, including ELISA testing with duplicate or triplicate assays - Specify from over 300 antibody pairs to build a custom ELISA kit meeting your specific requirements


Typical Applications

	•	Confirmation and quantification of antibody array data

	•	Detection of human, mouse, or rat protein levels

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ELISA Kits—Cell-based Protein Phosphorylation


Product Summary

	Cell-Based ELISA Kits come in flexible sizes: 96 assays on one plate, 192 assays on two plates, and sampler kits for screening of multiple phosphoproteins in one assay

Product Features

	•	Highly accurate and sensitive - Detects cell lines with no loss of activation state during procedure

	•	Minimizes hands-on time - Convenient, efficient, semi-quantitative, and non-radioactive material

	•	Works reliably with a wide range of cell lines

	•	Economically priced, allowing regular use

	•	Full range of technical support and testing services


Typical Applications

	•	Monitoring the activation or function of important biological pathways in cells

	•	Measuring the relative amount of protein phosphorylation to simultaneously screen the effects of various treatments, inhibitors, or activators in cultured cell lines

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Tissue MicroArrays—Human Normal and Cancer


Product Summary

	Tissue MicroArrays are developed with samples from multiple patients. Arrays are mounted on positively charged glass and coated with paraffin to prevent oxidation and enzyme contamination

Product Features

	•	Ideal for use as - Immunohistochemical (IHC) stains for protein expression arrays - In situ hybridization (ISH) stains for DNA/RNA assays

	•	A single array detects hundreds of tissue samples - Entire cohorts can be analyzed in one assay, and using a small amount of reagent

	•	Enables the use of image acquisition methods such as processing and database integration

	•	Standard histological block can be cored as many as 100 times - The original block is not destroyed; available for return to donor

	•	Full range of technical support and testing services


Typical Applications

	•	Monitoring cancer markers

	•	Identifying molecular targets, biomarkers, and mechanisms of drug action

	•	Discovering expression patterns for molecular classification of disease

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